A synthetic method for peptide-PEG-lipid conjugates.
Synonym: DSPE PEG2000, mPEG2000 DSPE, Methoxypolyethylene glycol DSPE. Description: mPEG DSPE is one of Nanocs phospholipid PEG derivatives that have a DSPE phospholipid attached to one PEG terminus.DSPE (1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine) is an 18 C saturated phospholipid with high hydrophobicity.DSPE PEG is a phospholipid PEG conjugate which has both hydrophilicity and.
DSPE-PEG(2000)-amine is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE (DSPE, Cay-15095). It has been used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents.
DSPE-PEG(2000) azide is used to prepare conjugated polymer nanoparticles. Packaging 20 mL Clear Glass Screw Cap Vial (880228P-500mg) 5 mL Amber Glass Screw Cap Vial (880228P-100mg) 5 mL Amber Glass Screw Cap Vial (880228P-10mg) 5 mL Amber Glass Screw Cap Vial (880228P-25mg).
PEG 2000 DSPE for synthesis (1,2-Distearoyl-phosphatidylethanolamine-methyl-polyethyleneglycol conjugate-2000) C43H83NO10P(C2H4O)nN.
Although PEG-DSPE exerted a little influence on the affinity of the cRGDpeptide,the K D valuewasstillatahighlevel.Hence,cRGDpep-tide (5% molar ratio of lipid) was a target ligand in the present study. Characterization of liposomes All the liposomes described in the present study were composed of the same lipid components: soy phospholipid (SPC.
DESIGN AND SYNTHESIS OF ANTITHROMBOTIC LIPOSOMAL PROTEIN CONJUGATE HAILONG ZHANG ABSTRACT Recent advances in the molecular bases of haemostasis have highlighted that endothelial thrombomodulin (TM) plays a critical role in local haemostasis by binding thrombin and subsequently converting protein C to its active form (APC).
A microfluidic hydrodynamic flow focusing technique enabling the formation of small and nearly monodisperse liposomes is investigated for continuous-flow synthesis of poly(ethylene glycol) (PEG)-modified and PEG-folate-functionalized liposomes for targeted drug delivery.